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| Identity |
| 3D Structure |
| Physicochemical data |
| Environmental fate |
| Mammal toxicology |
| Ecotoxicology |
| Metabolism |
| Safety classifications |
| Evaluation |
p-Methoxyacetophenone [100-06-1] |
| Theoretical prediction: In mammals p-methoxyacetophenone (1) may be either demethylated by cytochrome P450 to 4-hydroxyacetophenone (2) or reversible reduced by alcohol dehydrogenase at the carbonyl group to (6). The alcohol (6) as well as the phenolic metabolite (2) may then be conjugated with glucuronic acid to (9) or (8), the phenol also to the sulfate (7). These metabolites may then be excreted in urine. Microorganisms may also form an acetoxy group from the acetyl side chain of the phenol, which can be cleaved by esterases to acetic acid (5) and hydroquinone (4). Hydroquinone (4) can undergo a ring cleavage to yield afer several steps 3-oxoadipic acid (10) which may be mineralized via the beta-oxidation pathway to of to CO2 and H2O. |
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